Helga Refsum Selected Research

Homocysteine

1/2022	The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials.
1/2021	Anti-N-homocysteine-protein autoantibodies are associated with impaired cognition.
1/2021	Plasma Sulfur Amino Acids and Risk of Cerebrovascular Diseases: A Nested Case-Control Study in the EPIC-Norfolk Cohort.
6/2020	Body mass index determines the response of plasma sulfur amino acids to methionine loading.
11/2019	Association of Methionine to Homocysteine Status With Brain Magnetic Resonance Imaging Measures and Risk of Dementia.
1/2019	Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study.
10/2018	The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A.
1/2018	Homocysteine and Dementia: An International Consensus Statement.
12/2017	Elevated homocysteine and N-methyl-d-aspartate-receptor antibodies as a cause of behavioural and cognitive decline in 22q11.2 deletion syndrome.
1/2016	Homocysteine, B Vitamins, and Cognitive Impairment.

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Helga Refsum Research Topics

Disease

18	Obesity 10/2021 - 03/2008
17	Cognitive Dysfunction 01/2022 - 01/2004
13	Cardiovascular Diseases (Cardiovascular Disease) 09/2020 - 06/2002
12	Atrophy 01/2022 - 02/2009
12	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2010
9	Insulin Resistance 09/2022 - 03/2008
8	Dementia (Dementias) 11/2019 - 09/2010
7	Coronary Artery Disease (Coronary Atherosclerosis) 09/2020 - 09/2004
6	Hypertension (High Blood Pressure) 01/2019 - 01/2006
6	Hyperhomocysteinemia 01/2014 - 06/2003
5	Body Weight (Weight, Body) 01/2021 - 01/2011
4	Diarrhea 01/2014 - 06/2011
3	Stroke (Strokes) 01/2021 - 01/2002
3	Myocardial Infarction 01/2019 - 10/2017
3	Atherosclerosis 10/2017 - 09/2006
3	Type 2 Diabetes Mellitus (MODY) 09/2017 - 09/2015
3	Weight Loss (Weight Reduction) 09/2015 - 08/2011
3	Birth Weight (Birth Weights) 10/2014 - 01/2005
3	Prostatic Neoplasms (Prostate Cancer) 01/2011 - 06/2010
3	Neoplasms (Cancer) 06/2010 - 03/2008
3	Homocystinuria 09/2008 - 01/2004
3	Vascular Diseases (Vascular Disease) 09/2006 - 01/2003
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2021 - 09/2007
2	Tics (Tic) 01/2021 - 01/2021
2	Overweight 11/2020 - 12/2018
2	Chronic Disease (Chronic Diseases) 01/2020 - 01/2020
2	Osteoporosis 12/2019 - 05/2007
2	Osteoporotic Fractures 12/2019 - 05/2007
2	Inflammation (Inflammations) 01/2019 - 10/2011
2	Pernicious Anemia 12/2018 - 01/2018
2	Anemia 01/2017 - 03/2008
2	Neural Tube Defects (Exencephaly) 01/2017 - 03/2008
2	Respiratory Tract Infections (Respiratory Tract Infection) 09/2013 - 07/2007
2	Weight Gain 04/2013 - 01/2011
2	Pregnancy Complications 01/2004 - 02/2003
1	Sarcopenia 06/2022

Drug/Important Bio-Agent (IBA)

38	HomocysteineIBA 01/2022 - 01/2002
37	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022 - 01/2002
27	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2017 - 06/2003
20	Vitamin B Complex (B Vitamins)IBA 01/2022 - 01/2002
19	Cysteine (L-Cysteine)FDA Link 09/2022 - 02/2003
11	VitaminsIBA 01/2016 - 01/2002
10	Methionine (L-Methionine)FDA Link 01/2021 - 01/2004
8	Proteins (Proteins, Gene)FDA Link 10/2021 - 01/2011
8	Sulfur Amino AcidsIBA 01/2021 - 11/2010
7	Amino Acids FDA Link 01/2021 - 01/2012
6	Vitamin B 6IBA 07/2015 - 09/2004
5	Taurine FDA Link 09/2022 - 01/2011
5	Biomarkers (Surrogate Marker)IBA 06/2022 - 04/2013
5	CreatinineIBA 09/2020 - 01/2006
4	IronIBA 01/2021 - 07/2007
4	LipidsIBA 10/2017 - 01/2006
3	SulfurIBA 06/2022 - 01/2018
3	Branched-Chain Amino AcidsIBA 01/2021 - 08/2017
3	EnzymesIBA 01/2021 - 01/2003
3	Messenger RNA (mRNA)IBA 01/2021 - 01/2011
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 07/2015
3	Vitamin A (Retinol)FDA LinkGeneric 09/2020 - 10/2017
3	Glutathione (Reduced Glutathione)IBA 01/2020 - 01/2012
3	Tryptophan (L-Tryptophan)FDA Link 12/2019 - 01/2017
3	C-Reactive ProteinIBA 01/2019 - 01/2012
3	CystathionineIBA 01/2012 - 10/2004
3	Transcobalamins (Transcobalamin II)IBA 01/2011 - 06/2010
2	Leucine (L-Leucine)FDA Link 06/2022 - 12/2019
2	Isoleucine (L-Isoleucine)FDA Link 06/2022 - 12/2019
2	Cystine (L-Cystine)IBA 10/2021 - 04/2012
2	AutoantibodiesIBA 01/2021 - 01/2021
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2012
2	HDL LipoproteinsIBA 01/2021 - 10/2017
2	Dietary ProteinsIBA 12/2019 - 08/2017
2	KynurenineIBA 01/2019 - 01/2017
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2019 - 01/2016
2	Glutamic Acid (Glutamate)FDA Link 12/2018 - 08/2011
2	Methylmalonic AcidIBA 03/2014 - 01/2014
2	CholesterolIBA 01/2013 - 02/2003
2	ZincIBA 12/2011 - 06/2011
2	Prostate-Specific Antigen (Semenogelase)IBA 11/2010 - 06/2010
2	Coffee FDA Link 01/2006 - 02/2003
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 06/2003 - 01/2003
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 01/2022
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022
1	DisulfidesIBA 10/2021
1	Triglycerides (Triacylglycerol)IBA 01/2021
1	CarbonIBA 01/2021
1	AluminumIBA 01/2021
1	Essential Amino AcidsIBA 01/2021
1	HydrolasesIBA 01/2021
1	Aryldialkylphosphatase (Paraoxonase)IBA 01/2021
1	phenylacetic acid (phenylacetate)FDA Link 01/2021
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021
1	CopperIBA 01/2021
1	SiliconIBA 01/2021
1	fibroblast growth factor 21IBA 11/2020
1	Uric Acid (Urate)IBA 09/2020
1	cysteinylglycine (Cys-Gly)IBA 06/2020
1	Pharmaceutical PreparationsIBA 01/2020
1	Valine (L-Valine)FDA Link 12/2019
1	CalciumIBA 12/2019

Therapy/Procedure

4	Therapeutics 01/2022 - 01/2002
2	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2012 - 08/2011